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Microbiology @ SILS

Spatial SysBio Lab

The Spatial SysBio Lab investigates spatial aspects of signal transduction and regulation using systems biology approaches, combining molecular biology, quantitative imaging and computational modeling to understand cellular organization and decision-making processes.

What we do

We investigate spatial aspects of signal transduction pathways, cell polarity regulation and membrane organization using systems biology approaches. Our research combines molecular biology, quantitative imaging, and computational modeling to understand cellular organization and decision-making processes in microbial systems. We study how spatial organization influences signal transduction and cellular regulation at multiple scales, from molecular interactions to whole-cell behavior.

How we do it

Experimental approaches

We use advanced imaging techniques and molecular biology tools to study spatial organization of signaling pathways and cellular processes. Our experimental approaches include quantitative microscopy, genetic manipulation, and biochemical assays to investigate how cells organize their signaling machinery in space and time.

Data-driven analysis

We develop and apply computational models to understand how spatial organization influences cellular behavior. This includes modeling of signaling networks, membrane dynamics, and cellular decision-making processes. We integrate experimental data with theoretical frameworks to build predictive models of spatial organization and regulation in microbial systems.

Team

Marten Postma

Group leader